規(guī)格：50μL/100μL
貨號：PN0130
價格：1350元/50μL；2200元/100 μL
全稱 | mannose receptor, C type 1 |
別名 | hMR, C-type lectin domain family 13 member D-like, C-type lectin domain family 13 member D, CLEC13DL, CLEC13D |
抗體來源 | Mouse |
克隆類型 | Monoclonal |
交叉反應 | Human，Pig |
產(chǎn)品應用 | WB：1:5000-1:50000 IF： 1:200-1：800 IP: 0.5-4.0ug for 1.0-3.0 mg of total protein lysate IHC-P：1:10000-1:40000 |
理論/觀測到的分子量 | 166kDa / 170kDa |
細胞定位 | 細胞膜,內(nèi)體膜 |
性 狀 | Liquid |
濃 度 | 2000 ug/ml |
免 疫 原 | Recombinant protein corresponding to Human CD206
|
亞 型 | IgG |
純化方法 | Protein A purification |
Uniprot ID | |
緩 沖 液 | pH: 7.2,Preservative: 0.01% Sodium azide,Constituents: PBS, 40% Glycerol, 0.05% BSA |
保存條件 | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engμLfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellμLar carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia. This antibody recognizes the intracellμLar carboxy-terminal part of CD206 and MRC1L1.
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